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品种反应性 主要应用 宿主 格式 抗体类型 Dr WB M Purified Monoclonal Antibody 描述 产品目录编号 05-1512 描述 Anti-FMR1 Antibody, clone 6A15 Alternate Names - premature ovarian failure 1
- Protein FMR-1
- fragile X mental retardation 1
背景信息 Fragile X Mental Retardation 1 (FMR1) is a RNA-binding protein that is associated to polysomes and may be involved in the transport of mRNA from the nucleus to the cytoplasm. Defects in FMR1 are the cause of Fragile X syndrome, which is a common genetic disease characterized by moderate to severe mental retardation, macroorchidism, large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region. 产品信息 格式 Purified 控制 - Drosophila Schneider L2 cell lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-FMR1 Antibody, clone 6A15 is an antibody against FMR1 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 His-tagged recombinant protein corresponding to Drosophila FMR1. 表位 Unknown 克隆 6A15 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes FMR1. 同种型 IgG1κ 品种反应性 Drosophila Species Reactivity Note Demonstrated to react with Drosophila. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_611645.1
基因符号 - POF1
- FMR1
- FMRP
- FRAXA
- POF
纯化方法 Protein G purfied UniProt编号 - Q9NFU0
UniProt汇总 FUNCTION: RNA-binding protein that associates with translating ribosomes and acts as a negative translational regulator of specific mRNAs. Represses translation of futsch to regulate microtubule-dependent synaptic growth and function. Part of the RNA interference (RNAi)-related apparatus; double-stranded RNA induces potent and specific gene silencing. Regulates photoreceptor structure and neurotransmission in the eye. Required for stability of the central pair of microtubules in the spermatid axoneme.
SUBUNIT STRUCTURE: Homodimer. Interacts with futsch and Sra-1. Interacts with the ribosome to form a ribonucleoprotein (RNP) complex, involved in translation regulation, with mRpL5 and mRpL11 on the ribosomal surface. The complex also contains AGO2, Dcr-1 and Rm62.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Until early gastrulation, expression is uniformly distributed in the embryo. At mid-gastrulation (stage 11), expression everywhere with discernible concentration in the mesoderm. After gastrulation (stage 14), expression is significantly elevated in the mesoderm, ventral nerve cord, and brain. At stage 16, elevated expression is also seen in the muscle. Highly expressed in nervous system throughout later development. Highly expressed in testes in the early stages of spermatogenesis before spermatid individualization.
DEVELOPMENTAL STAGE: Expressed both maternally and zygotically in embryos.
SEQUENCE SIMILARITIES: Belongs to the FMR1 family.
Contains 2 KH domains.产品使用声明 质量保证 Evaluated by Western Blot in Drosophila Schneider L2 cell lysate.
Western Blot Analysis: 0.1 µg/ml of this antibody detected FMR1 on 10 µg of Drosophila Schneider L2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution.包装信息 数量 100 µg
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