- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,05-848,Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3
产品名称：Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3
产品型号：05-848
This Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3 is validated for use in WB, IC, IH for the detection of Neurofilament.
merck millipore,默克密理博,05-848,Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M IHC, WB, ICC M Ascites Monoclonal Antibody 描述 产品目录编号 05-848 品牌系列 Upstate
商名 - Upstate
描述 Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3 产品信息 格式 Ascites 演示 Ascites in 0.05% sodium azide and 30% glycerol 应用 应用 This Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3 is validated for use in WB, IC, IH for the detection of Neurofilament. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
生物信息 免疫原品种 Trp-E fusion protein corresponding to residues 846-1072 of rat neurofilament heavy chain. 克隆 3G3 宿主 Mouse 特异性 Neurofilament heavy chain 同种型 IgG 品种反应性 RatMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_021076
基因符号 - NFH
- NEFH
- NF-H
- KIAA0845
纯化方法 Ascites UniProt编号 - P12036
UniProt汇总 FUNCTION: SwissProt: P12036 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
SIZE: 1026 amino acids; 112480 Da
PTM: There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
DISEASE: SwissProt: P12036 # Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
SIMILARITY: SwissProt: P12036 ## Belongs to the intermediate filament family.产品使用声明 质量保证 Routinely evaluated by immunoblot on rat brain microsomal preparation (12-144). 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
上一件merck millipore产品：merck millipore,默克密理博,AB19026,Anti-ADAM 10 Antibody, CT
下一件merck millipore产品：merck millipore,默克密理博,MAB883,Anti-HIV Antibody, gp 120, clone 4B9.1
相关产品
merck millipore,默克密理博,14-790M,PI3 Kinase (p110α/p65α), 250 µg
merck millipore,默克密理博,AB19026,Anti-ADAM 10 Antibody, CT
merck millipore,默克密理博,MAB883,Anti-HIV Antibody, gp 120, clone 4B9.1
merck millipore,默克密理博,05-1512,Anti-FMR1 Antibody, clone 6A15
merck millipore,默克密理博,SF-754,UVRAG; Human, Cyanine 3, RNA Detection Probe,SmartFlare
