merck millipore,默克密理博,9015,Human Proinsulin Insulin

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Merck Millipore 默克密理愽

描述
产品目录编号	9015
描述	Human Proinsulin Insulin
背景信息	These iodinated hormonos are HPLC purified and prepared fresh monthly.

应用
应用	Iodinated Human proinsulin -HPLC purified & prepared fresh monthly.
应用说明	appropriate label hydrating buffer if kit replacement or assay buffer of choice

生物信息
品种	Human
Entrez基因编号	NM_000207.2
Entrez基因汇总	After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
基因符号	insulin INS proinsulin
标签	¹²⁵Iodine
UniProt编号	P01308
UniProt汇总	FUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. SIZE: 110 amino acids; 11981 Da SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds. SUBCELLULAR LOCATION: Secreted. DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]. SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.

理化信息
放射性	<3 μCi

储存和货运信息
存储条件	2–8 °C

包装信息
数量	250 tubes

merck millipore,默克密理博,9015,Human Proinsulin Insulin

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