merck millipore,默克密理博,528113,PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4

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Merck Millipore 默克密理愽

merck millipore,默克密理博,528113,PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem

经验配方	CAS号
C₂₁H₂₄N₄O₂	663619-89-4

描述
概述	A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC₅₀ = 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.
产品目录编号	528113
品牌系列	Calbiochem®
同义词	(±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one, PI 3-K Inhibitor VI

参考
参考	Chaussade, C., et al. 2007. Biochem. J. 404, 449. Cosemans, J.M, et al. 2006. Blood 108, 3045. Condliffe, A.M., et al. 2005. Blood 106, 1432. Jackson, S.P., et al. 2005. Nat. Med. 11, 507.

生物信息
主靶	PI 3-Kβ
主靶IC₅₀	0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively
纯度	≥97% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,528113,PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem

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