merck millipore,默克密理博,662035,U-73122 - CAS 112648-68-7

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merck millipore,默克密理博,662035,U-73122 - CAS 112648-68-7 - Calbiochem
产品名称：U-73122 - CAS 112648-68-7 - Calbiochem
产品型号：662035
Inhibits agonist-induced phospholipase C activation (IC₅₀ = 1-2.1 µM) in human platelets and neutrophils.

merck millipore,默克密理博,662035,U-73122 - CAS 112648-68-7 - Calbiochem

产品介绍

merck millipore,默克密理博,662035,U-73122 - CAS 112648-68-7 - Calbiochem

重要规格表

经验配方	CAS号
C₂₉H₄₀N₂O₃	112648-68-7

描述
概述	Inhibits agonist-induced phospholipase C activation (IC₅₀ = 1-2.1 µM) in human platelets and neutrophils. Inhibits ET-1 and parathyroid hormone-induced Ca²⁺ transients (IC₅₀ = 800 nM and 500 nM, respectively). Also inhibits agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Acts as a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces (IC₅₀ = 50 nM). Reported to abolish T lymphoma cell invasion into fibroblast monolayers.
产品目录编号	662035
品牌系列	Calbiochem®
同义词	1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2,5-dione

参考
参考	Stam, J.C., et al. 1998. EMBO J. 17, 4066. Smith, R.J., et al. 1996. J. Pharmacol. Exp. Ther. 278, 320. Tatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595. Wang, X.D., et al. 1994. Biochim. Biophys. Acta 1223, 101. Bleasdale, J.E., and Fisher, S.K. 1993. Neuroprotocols: A Companion to Methods in Neurosci. 3, 125. Wu, H., et al. 1992. Biochemistry 31, 3370. Yule, D.I., and Williams, J.A. 1992. J. Biol. Chem. 267, 13830. Thompson, A.K., et al. 1991. J. Biol. Chem. 266, 23856.

参考

Stam, J.C., et al. 1998. EMBO J. 17, 4066.
Smith, R.J., et al. 1996. J. Pharmacol. Exp. Ther. 278, 320.
Tatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595.
Wang, X.D., et al. 1994. Biochim. Biophys. Acta 1223, 101.
Bleasdale, J.E., and Fisher, S.K. 1993. Neuroprotocols: A Companion to Methods in Neurosci. 3, 125.
Wu, H., et al. 1992. Biochemistry 31, 3370.
Yule, D.I., and Williams, J.A. 1992. J. Biol. Chem. 267, 13830.
Thompson, A.K., et al. 1991. J. Biol. Chem. 266, 23856.

产品信息
CAS号	112648-68-7
具有ATP竞争性	N
形式	Off-white solid
Hill配方	C₂₉H₄₀N₂O₃
化学配方	C₂₉H₄₀N₂O₃
Molar Mass	464.7
可逆	N
结构配方图像

生物信息
主靶	Agonist-induced phospholipase C activation
主靶IC₅₀	1-2.1 µM against agonist-induced phospholipase C activation in human platelets and neutrophils; 800 nM and 500 nM, respectively, against ET-1 and parathyroid hormone-induced Ca2+ transients; 50 nM against human polymorphonuclear neutrophil adhesion
纯度	≥98% by HPLC

理化信息
细胞可渗透	N
溶解度	CHCl₃, DMSO, or EtOH (Reconstitute in DMSO just prior to use)

安全信息
R相	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S相	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Irritant
储存	+15°C to +30°C
无需冷冻	No
特殊指南	Unstable in DMSO and ethanol; reconstitute in anhydrous DMSO or ethanol just prior to use. Following reconstitution in anhydrous chloroform, aliquot into single use volumes, evaporate to dryness under a stream of nitrogen, and freeze (-20°C. Dried aliquots are stable for up to 6 months at -20°C. ); Reconstitute dried aliquots in anhydrous DMSO or anhydrous ethanol just prior to use.