merck millipore,默克密理愽
  • merck millipore,默克密理博,616370,Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem

  • merck millipore,默克密理博,616370,Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem

    产品名称：Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem
    产品型号：616370
    A competitive and reversible inhibitor of esterases and proteases.

    merck millipore,默克密理博,616370,Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616370,Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem

    重要规格表

    CAS号
    9087-70-1
    描述
    概述 A competitive and reversible inhibitor of esterases and proteases. Forms a tight complex with and blocks the active site of the enzymes. Inhibits a number of different proteases, including chymotrypsin, coagulation factors involved in the prephase of blood clotting, kallikrein (Kd = 1 x 10-7 M), plasmin (Kd = 2.3 x 10-10 M) , tissue and leukocytic proteinases, and trypsin (Kd = 5 x 10-14 M). Does not inhibit Factor Xa and thrombin. It is relatively acid- and heat-stable. Useful as a serine protease inhibitor during purification of proteins and in studies of zymogen activation systems. Reported to suppress virus HA cleavage and limit reproduction of human and avian influenza viruses with a single arginine in the HA cleavage site.
    Effectively inhibits target proteases at equimolar concentration.
    Note: 1 KIU = 0.025 antiplasmin units (APU) = 0.0016 trypsin inhibitor units (using porcine trypsin) = 0.0009756 trypsin inhibitor units (using bovine trypsin).
    产品目录编号 616370
    品牌系列 Calbiochem®
    同义词 Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor
    参考
    参考 Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
    Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
    Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
    Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
    Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
    McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
    Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
    Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
    Kassell, B., et al. 1970. Methods Enzymol. 19, 845.
    产品信息
    CAS号 9087-70-1
    活性 ≥5500 KIU/mg dry weight
    具有ATP竞争性 N
    形式 White to off-white crystalline solid
    Molar Mass 6512
    吸湿 Hygroscopic
    PI 10.5
    可逆 Y
    生物信息
    主靶 chymotrypsin
    主靶IC50 Kd = 1 x 10-7 M, 2.3 x 10-10 M, 5 x 10-14 M, against kallikrein, plasmin, and trypsin, respectively
    纯度 ≥95% by gel filtration
    理化信息
    细胞可渗透 N
    污染物 endotoxin: ≤10 EU/mg
    pH值 optimum 5 - 7
    溶解度 H₂O
    GHS安全信息
    RTECS YN5080000
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.

    merck millipore,默克密理博,616370,Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem

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