merck millipore,默克密理愽
  • merck millipore,默克密理博,658408,AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem

  • merck millipore,默克密理博,658408,AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem

    产品名称：AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem
    产品型号：658408
    A cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 that displays apoptotic and antiproliferative properties.

    merck millipore,默克密理博,658408,AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,658408,AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₃F₃N₂O₃581797-29-7
    描述
    概述 A cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC50 = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo.
    产品目录编号 658408
    品牌系列 Calbiochem®
    同义词 NSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4
    参考
    参考 Gu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269.
    产品信息
    CAS号 581797-29-7
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₁₈H₁₃F₃N₂O₃
    化学配方 C₁₈H₁₃F₃N₂O₃
    Molar Mass 362.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 apoptotic and antiproliferative properties
    主靶IC50 1.7 µM, 2.8 µM and 6.1 µM for displaying apoptotic and antiproliferative properties in 2E8, Baf/3 and Jurkat cells, respectively
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,658408,AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,869008,Growth Hormone, Human Pituitary, Iodination Grade
下一件merck millipore产品：merck millipore,默克密理博,513024,PD 151746 - CAS 179461-52-0 - Calbiochem


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