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merck millipore,默克密理博,658401,AG 490 - CAS 133550-30-8 - Calbiochem
产品名称：AG 490 - CAS 133550-30-8 - Calbiochem
产品型号：658401
A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC₅₀ = 100 nM).
merck millipore,默克密理博,658401,AG 490 - CAS 133550-30-8 - Calbiochem
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重要规格表
经验配方 CAS号 C₁₇H₁₄N₂O₃ 133550-30-8 描述 概述 A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Inhibition of JAK2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. Inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658411) in DMSO is also available. 产品目录编号 658401 品牌系列 Calbiochem®
同义词 α-Cyano-(3,4-dihydroxy)-N-benzylcinnamide, Tyrphostin B42, (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI 参考 参考 Jaleel, M., et al. 2004. Biochemistry 43, 8247.
Eriksen, K.W., et al. 2001. Leukemia 15, 787.
Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
Meydan, N., et al. 1996. Nature 379, 645.
Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.产品信息 CAS号 133550-30-8 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₁₇H₁₄N₂O₃ 化学配方 C₁₇H₁₄N₂O₃ Molar Mass 294.3 可逆 Y 结构配方图像 生物信息 主靶 epidermal growth factor receptor kinase autophosphorylation 主靶IC50 100 nM against epidermal growth factor receptor kinase autophosphorylation 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
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