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品种反应性 主要应用 宿主 格式 抗体类型 M WB R Purified Monoclonal Antibody 描述 产品目录编号 05-534 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-Raf-1 (Ser338) Antibody 产品信息 格式 Purified 演示 PBS, pH 7.4, with 0.09% sodium azide 应用 应用 Detect phospho-Raf-1 (Ser338) using this Anti-phospho-Raf-1 (Ser338) Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Peptide corresponding to residues 334-347 of Raf-1; recognizes phosphorylated Raf-1 on Serine 338. 宿主 Rat 特异性 Raf-1 phosphorylated at Ser 338, irrespective of the phosphorylation state of Tyr341; does not bind to unactive Raf-1 or Raf-1 peptides phosphorylated only at Tyr341 or Ser339 同种型 IgG1 品种反应性 Mouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002880
Entrez基因汇总 Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. [Contributed text] 基因符号 - C-RAF
- RAF1
- cRaf
- Raf-1
- c-Raf
- RAF
- CRAF
修改 - Phosphorylation
纯化方法 Protein A chromatography UniProt编号 - P04049
UniProt汇总 FUNCTION: SwissProt: P04049 # Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3.
COFACTOR: Binds 2 zinc ions per subunit.
SIZE: 648 amino acids; 73052 Da
SUBUNIT: Interacts with Ras proteins. The interaction with Ras is antagonized by RIN1. Weakly interacts with RIT1 (By similarity). Interacts with STK3, which inhibits its pro-apoptotic activity.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY:SwissProt: P04049 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain. & Contains 1 RBD (Ras-binding) domain.产品使用声明 质量保证 routinely evaluated by immunoblot on PDGF stimulated 3T3/NIH cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 100 µg
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