- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS461 描述 Anti-SHOC2 Antibody Alternate Names - Protein sur-8 homolog
- Leucine-rich repeat protein SHOC-2
- Ras-binding protein Sur-8
- SOC2
- Protein soc-2 homolog
背景信息 The Leucine-rich repeat protein SHOC-2 (SHOC2) is the regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and plays a key role in MAPK pathway activation. Upon RAS activation, SHOC2 acts as a positive modulator of the RAS-MAPK signaling via specifically allowing PP1c to dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity. SHOC2 localizes to cytoplasm when inactive but rapidly translocates to the nucleus when activated, such as during growth factor stimulation. Thus, as expected, SHOC2 also participates in FGF receptor signaling. Molecularly, SHOC2 is a scaffold protein that brings together activated Ras (activated via G-protein coupled receptors and the interaction of GTP to GDP) and Raf, which then facilitates the transfer of the phospho-Raf phosphate to other proteins for the activation of the MAP Kinase pathway for gene activation. Defects in SHOC2 lead to a type of multi-symptomatic disorder termed the Noonan Syndrome Loss of Anagen Hair (NSLAH) that affects everything from skeletal formation to facial features and many organs including the brain, skin, muscles, and heart. EMD Millipore’s Anti-SHOC2 rabbit polyclonal antibody has been tested in western blotting and immunohistochemistry in human samples. 产品信息 格式 Affinity Purified 控制 - Jurkat cell lysate
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Detect Leucine-rich repeat protein SHOC-2 using this rabbit polyclonal antibody, Anti-SHOC2 Antibody validated for use in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected SHOC2 in human spleen tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human SHOC2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - SHOC2
纯化方法 Antigen Affinity purified UniProt编号 - Q9UQ13
产品使用声明 质量保证 Evaluated by Western Blotting in Jurkat cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected SHOC2 in 15 µg of Jurkat cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,204897,Complement C4b, Human
下一件merck millipore产品：merck millipore,默克密理博,ABE480,Anti-Centrin-2 Antibody
相关产品
merck millipore,默克密理博,05-534,Anti-phospho-Raf-1 (Ser338) Antibody
merck millipore,默克密理博,MAB8515-KC,Anti-Human Metapneumovirus (MPV) Purified, clone 2D7 (1mg) KC
merck millipore,默克密理博,17-10147,LentiBrite ™ GFP-HMGB1 Lentiviral Biosensor
merck millipore,默克密理博,428016,Sodium n-Dodecyl Sulfate, High Purity - CAS 151-21-3 - Calbiochem
merck millipore,默克密理博,204897,Complement C4b, Human
merck millipore,默克密理博,ABE480,Anti-Centrin-2 Antibody
merck millipore,默克密理博,487955,NOC-12 - CAS 146724-89-2 - Calbiochem
merck millipore,默克密理博,164606,Aminopeptidase N/CD13 Inhibitor - Calbiochem
merck millipore,默克密理博,AG313,Glutamate Receptor δ 1/2 Control Peptide for AB1514
merck millipore,默克密理博,DC02L,Goat Anti-Mouse IgG Peroxidase Conjugate