merck millipore,默克密理愽
  • merck millipore,默克密理博,654270,TNP-470 - CAS 129298-91-5 - Calbiochem

  • merck millipore,默克密理博,654270,TNP-470 - CAS 129298-91-5 - Calbiochem

    产品名称：TNP-470 - CAS 129298-91-5 - Calbiochem
    产品型号：654270
    A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity, without affecting the inhibitory activity of MetAP2 against HRI- catalyzed eIF-2α phosphory More>>

    merck millipore,默克密理博,654270,TNP-470 - CAS 129298-91-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,654270,TNP-470 - CAS 129298-91-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₂₈CINO₆129298-91-5
    描述
    概述 A cell-permeable Fumagillin (Cat. No. 344845) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1 nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation. A potent endothelial cytostasis inducer (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2 to 100 mg/kg in mice and rats; s.c.).
    产品目录编号 654270
    品牌系列 Calbiochem®
    同义词 AGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470
    参考
    参考 Zhang, Y., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6427.
    Sin, N., et al. Proc. Natl. Acad. Sci. USA 94, 6099.
    Yamaoka, M., et al. 1993. Cancer Res. 53, 4262.
    Kusaka, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
    Ingber, D., et al. 1990. Nature 348, 555.
    产品信息
    CAS号 129298-91-5
    形式 White to light yellow solid
    Hill配方 C₁₉H₂₈CINO₆
    化学配方 C₁₉H₂₈CINO₆
    Molar Mass 401.9
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Irritant
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,654270,TNP-470 - CAS 129298-91-5 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,ABE40,Anti-PABPC1/C3 Antibody
下一件merck millipore产品：merck millipore,默克密理博,567715,N-SMase Inhibitor, GW4869 - CAS 6823-69-4 - Calbiochem


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