merck millipore,默克密理愽
  • merck millipore,默克密理博,616458,TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem

  • merck millipore,默克密理博,616458,TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem

    产品名称：TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem
    产品型号：616458
    The TGF-β RI Kinase Inhibitor VII, also referenced under CAS 666729-57-3, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dep More>>

    merck millipore,默克密理博,616458,TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616458,TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₂₁NO₄666729-57-3
    描述
    概述 A cell-permeable quinoline compound that acts a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity (IC50 = 0.63 µM), while inhibiting c-Src only at higher concentrations (IC50 = 13 µM). Shown to block TGF-β-induced Smad2 phosphorylation and Smad2/3 transcription activity (IC50 = 0.5 and 0.37 µM, respectively) in human lung cancer epithelial cell line A549.
    产品目录编号 616458
    品牌系列 Calbiochem®
    同义词 1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII
    参考
    参考 Shimizu, T., et al. 2008. J. Med. Chem. 51, 3326.
    产品信息
    CAS号 666729-57-3
    形式 Off-white solid
    Hill配方 C₂₁H₂₁NO₄
    化学配方 C₂₁H₂₁NO₄
    Molar Mass 351.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    安全信息
    R相 R: 20/21/22

    Harmful by inhalation, in contact with skin and if swallowed.
    S相 S: 22-24/25-36-45

    Do not breathe dust.
    Avoid contact with skin and eyes.
    Wear suitable protective clothing.
    In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,616458,TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,251500,DAF-2 - CAS 205391-01-1 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,216100,Carboplatin - CAS 41575-94-4 - Calbiochem


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