merck millipore,默克密理愽
  • merck millipore,默克密理博,614853,Topoisomerase II Inhibitor, BNS-22 - Calbiochem

  • merck millipore,默克密理博,614853,Topoisomerase II Inhibitor, BNS-22 - Calbiochem

    产品名称：Topoisomerase II Inhibitor, BNS-22 - Calbiochem
    产品型号：614853
    The Topoisomerase II Inhibitor, BNS-22 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,614853,Topoisomerase II Inhibitor, BNS-22 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,614853,Topoisomerase II Inhibitor, BNS-22 - Calbiochem

    重要规格表

    经验配方
    C₂₄H₂₅NO₅
    描述
    概述 A potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50 = 2.8 µM and 0.42 µM for TOP2α and TOP2β, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of γ-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10 µM. It also exhibits significant anti-proliferative activities against several human cancer cell lines.
    产品目录编号 614853
    品牌系列 Calbiochem®
    同义词 BNS-22
    参考
    参考 Kawatani, M., et al. 2011. Chem Biol. 18, 743.
    产品信息
    形式 White solid
    Hill配方 C₂₄H₂₅NO₅
    化学配方 C₂₄H₂₅NO₅
    Molar Mass 407.46
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,614853,Topoisomerase II Inhibitor, BNS-22 - Calbiochem

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