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merck millipore,默克密理博,613810,TNAP Inhibitor - CAS 496014-13-2 - Calbiochem
产品名称：TNAP Inhibitor - CAS 496014-13-2 - Calbiochem
产品型号：613810
The TNAP Inhibitor, also referenced under CAS 496014-13-2, controls the biological activity of TNAP. This small molecule/inhibitor is primarily used for Cell Structure applications.
merck millipore,默克密理博,613810,TNAP Inhibitor - CAS 496014-13-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₇H₁₆N₂O₄S 496014-13-2 描述 概述 A cell-permeable quinolinyl-benzenesulfonamide compound that acts as a potent reversible inhibitor against tissue-nonspecific (TN) alkaline phosphatase (AP) activity (IC50 = 190 nM) with CYP2C19 being the only other known target, while exhibiting little or no inhibitory activity in over 250 assays involving other enzymes, including, but not limited to, placental and intestinal APs (IC50 > 100 µM), PHOSPHO1 phosphatase, and NPP1 phosphodiesterase. Kinetic studies indicate that the inhibition is uncompetitive with respect to the phosphate donor substrate and noncompetitive with respect to the acceptor substrate, indicating an allosteric inhibition mechanism. Subcutaneous dosing in rats in vivo is reported to result in plasma inhibitor concentrations in the therapeutic range (Cmax = 1.5 µg/ml 1 hr after 4.13 mg/kg by s.c.). 产品目录编号 613810 品牌系列 Calbiochem®
同义词 2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide, Tissue-Nonspecific Alkaline Phosphatase Inhibitor, MLS-0038949 参考 参考 Dahl, R., et al. 2009. J. Med. Chem. 52, 6919. 产品信息 CAS号 496014-13-2 形式 White solid Hill配方 C₁₇H₁₆N₂O₄S 化学配方 C₁₇H₁₆N₂O₄S Molar Mass 344.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and store at (4°C). Stock solutions are stable for up to 6 months at 4°C. 包装信息 惰性气体下包装 Packaged under inert gas
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