merck millipore,默克密理博,442640,L3MBTL1 Ligand, UNC669

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Merck Millipore 默克密理愽

merck millipore,默克密理博,442640,L3MBTL1 Ligand, UNC669 - Calbiochem

经验配方
C₁₅H₂₀BrN₃O

描述
概述	A nicotinamido-pyrrolidine compound that targets the second MBT (Malignant Brain Tumor) module of "chromatin lock" L3MBTL1 (Lethal 3 MBT-Like protein 1; K_d = 5 µM by Isothermal titration calorimetry) that "reads"/binds mono- and dimethyl-lysine modified histones as well as other proteins involved in transcription, such as p53 and Rb, via methylation-dependent recognition. Shown to effectively compete against FAM-labeled, monomethylated Histone H3 (1-15) peptide (H3K9Me₁) binding to L3MBTL1 (K_d = 10 µM in a FP displacement assay) and exhibit higher affinity toward L3MBTL1 than L3MBTL3 and L3MBTL4 (IC₅₀ = 6, 35, and 69 µM, respectively, in a luminescent peptide competitive binding assay), while displaying no detectable binding toward four other methyl-lysine-binding proteins, the BMT domain-containing SFMBT1 and MBTD1, the PHD (Plant Homeodomain) finger-containing PHF13 (PHD finger 13), and the chromo domain-containing CBX7 (chromobox 7). As of end of 2012, no published data is available regarding the molecule's permeability or biological activity in cells.
产品目录编号	442640
品牌系列	Calbiochem®
同义词	5-Bromo-N-(4-(pyrrolidinyl)piperidinyl)nicotinamide

参考
参考	Herold, J.M., et al. 2011. J. Med. Chem. 54, 2504.

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO or H₂O

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,442640,L3MBTL1 Ligand, UNC669 - Calbiochem

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