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merck millipore,默克密理博,572650,SU9516 - CAS 666837-93-0 - Calbiochem
产品名称：SU9516 - CAS 666837-93-0 - Calbiochem
产品型号：572650
A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells.
merck millipore,默克密理博,572650,SU9516 - CAS 666837-93-0 - Calbiochem
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重要规格表
经验配方 CAS号 C₁₃H₁₁N₃O₂ 666837-93-0 描述 概述 A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks; IC50 = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). It shows no significant effect (IC50 >10 µM) on the activities of PKC, p38, PDGFRβ, or EGFR. Inhibits the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F. 产品目录编号 572650 品牌系列 Calbiochem®
同义词 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one 参考 参考 Yu, B., et al. 2002. Biochem. Pharmacol. 64, 1091.
Lane, M.E., et al. 2001. Cancer Res. 61, 6170.产品信息 CAS号 666837-93-0 具有ATP竞争性 Y 形式 Yellow solid Hill配方 C₁₃H₁₁N₃O₂ 化学配方 C₁₃H₁₁N₃O₂ Molar Mass 241.3 可逆 Y 结构配方图像 生物信息 主靶 Cdk2/A 主靶IC50 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,HTS146M,ChemiSCREEN™ Membrane Preparation Recombinant Human mGLU2 Metabotropic Glutamate Receptor
下一件merck millipore产品：merck millipore,默克密理博,420298,K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem
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