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merck millipore,默克密理博,420298,K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem
产品名称：K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem
产品型号：420298
A cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases.
merck millipore,默克密理博,420298,K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₇H₂₁N₃O₅ 97161-97-2 描述 概述 A cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297). 产品目录编号 420298 品牌系列 Calbiochem®
参考 参考 Cools, J., et al. 2004. Cancer Res. 64, 6385.
Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
Tapley, P., et al. 1992. Oncogene 7, 371.
Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.产品信息 CAS号 97161-97-2 具有ATP竞争性 Y 形式 White solid Hill配方 C₂₇H₂₁N₃O₅ 化学配方 C₂₇H₂₁N₃O₅ Molar Mass 467.5 可逆 Y 结构配方图像 生物信息 主靶 CaM kinase II 主靶Ki 1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMF or DMSO GHS安全信息 RTECS NZ0550000 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
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