merck millipore,默克密理愽
  • merck millipore,默克密理博,567060,Siomycin A, Streptomyces sioyaensis - Calbiochem

  • merck millipore,默克密理博,567060,Siomycin A, Streptomyces sioyaensis - Calbiochem

    产品名称：Siomycin A, Streptomyces sioyaensis - Calbiochem
    产品型号：567060
    A cell-permeable thiostrepton family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis by interfering with rRNA binding.

    merck millipore,默克密理博,567060,Siomycin A, Streptomyces sioyaensis - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,567060,Siomycin A, Streptomyces sioyaensis - Calbiochem

    重要规格表

    经验配方
    C₇₁H₈₁N₁₉O₁₈S₅
    描述
    概述 A cell-permeable thiostrepton (Cat. No. 598226) family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding. Shown to inhibit mammalian FoxM1 (forkhead box M1) function in C3 cells by negatively regulating its transcriptional activity (IC50 ≤5 µM), phosphorylation, as well as mRNA (>60% reduction at 10 µM) and protein (>90% reduction at 20 µM) abundance. Selectively induces apoptosis in SV40-transformed MRC-5 human fetal lung fibroblasts, but not the non-transformed wild-type cells.
    产品目录编号 567060
    品牌系列 Calbiochem®
    同义词 NSC 285116, FOXM1 Inhibitor II
    参考
    参考 Priller, M., et al. 2011. Clin. Cancer Res. 17, 6791.
    Radhakrishnan, S.K., et al. 2006. Cancer Res. 66, 9731.
    Erdal, H., et al. Proc. Natl. Acad. Sci. USA 102, 192.
    Lentzen, G., et al. 2003. Chem. Biol. 10, 769.
    产品信息
    形式 White solid
    Hill配方 C₇₁H₈₁N₁₉O₁₈S₅
    化学配方 C₇₁H₈₁N₁₉O₁₈S₅
    Molar Mass 1648.8
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    R相 R: 20/21/22

    Harmful by inhalation, in contact with skin and if swallowed.
    S相 S: 22-24/25-36/37-45

    Do not breathe dust.
    Avoid contact with skin and eyes.
    Wear suitable protective clothing and gloves.
    In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Harmful
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,567060,Siomycin A, Streptomyces sioyaensis - Calbiochem

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