merck millipore,默克密理博,MABD42,Anti-Cyp7a1 Antibody, clone 15B9.1

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H, R	IHC, WB	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABD42
描述	Anti-Cyp7a1 Antibody, clone 15B9.1
Alternate Names	Cytochrome P450 7A1 Cholesterol 7-alpha-monooxygenase CYPVII Cholesterol 7-alpha-hydroxylase
背景信息	Cytochrome P450 7A1 (CYP7A1, CYPVII), also known as cholesterol 7-alpha-monooxygenase or cholesterol 7-alpha-hydroxylase, belongs to the cytochrome P450 family and is important for cholesterol homeostasis. CYP7A1 catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Detected primarily in the liver, CYP7A1 catalyzes the following reaction: Cholesterol + NADPH + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. CYP7A1 is up-regulated by glucose and by cholestyramine, and is down-regulated by chenodeoxycholic acid.

产品信息
格式	Purified
控制	Human liver tissue lysate
演示	Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	This Cyp7a1 antibody is validated for use in WB & IHC for the detection of the Cyp7a1 protein.
主要应用	Immunohistochemistry Western Blotting
应用说明	Imunnohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected Cyp7a1 in rat and human liver tissue.

生物信息
免疫原品种	GST-tagged recombinant protein corresponding to human Cyp7a1.
克隆	15B9.1
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
同种型	IgG2aκ
品种反应性	MouseHumanRat
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_000771
基因符号	CYP7 CYP7A1
纯化方法	Protein G purified
UniProt编号	P22680

产品使用声明
质量保证	Evaluated by Western Blotting in human liver tissue lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected Cyp7a1 in 10 µg of human liver tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABD42,Anti-Cyp7a1 Antibody, clone 15B9.1

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