merck millipore,默克密理博,688002,InSolution™ Y-27632 in DMSO

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Merck Millipore 默克密理愽

merck millipore,默克密理博,688002,InSolution™ Y-27632 in DMSO - Calbiochem

经验配方
C₁₄H₂₁N₃O•2HCl•H₂O

描述
概述	A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (K_i = 140 nM for p160^ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKC_ε than p160^ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca²⁺ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H₂O and the solid form of this compound (Cat. No. 688000) are also available.
产品目录编号	688002
品牌系列	Calbiochem®
同义词	(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI

参考
参考	Watanabe, K., et al. 2007. Nature Biotech. 25, 681. Chitaley, K., et al. 2001. Nat. Med. 7, 119. Davies, S.P., et al. 2000. Biochem. J. 351, 95. Narumiya, S., et al. 2000. Methods Enzymol. 325, 273. Hirose, M., et al. 1998. J. Cell Biol. 141, 1625. Maekawa, M., et al. 1999. Science 285, 895. Uehata, M., et al. 1997. Nature 389, 990.

产品信息
形式	Liquid
配方	A 10 mM (1 mg/296 µl) solution of Y-27632 (Cat. No. 688000)in DMSO.
Hill配方	C₁₄H₂₁N₃O•2HCl•H₂O
化学配方	C₁₄H₂₁N₃O•2HCl•H₂O
Molar Mass	338.3
吸湿	Hygroscopic
结构配方图像

生物信息
纯度	≥95% by HPLC

安全信息
R相	R: 36/38 Irritating to eyes and skin.

储存和货运信息
货运代码	Dry Ice Only
毒性	Irritant
储存	≤ -70°C
避光	Protect from light
吸湿	Hygroscopic
避免冻结 / 解冻	Avoid freeze/thaw
无需冷冻	No
特殊指南	Following initial thaw, aliquot and freeze (-20°C).

merck millipore,默克密理博,688002,InSolution™ Y-27632 in DMSO - Calbiochem

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