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merck millipore,默克密理博,567020,Simvastatin - CAS 79902-63-9 - Calbiochem
产品名称：Simvastatin - CAS 79902-63-9 - Calbiochem
产品型号：567020
A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation.
merck millipore,默克密理博,567020,Simvastatin - CAS 79902-63-9 - Calbiochem
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重要规格表
经验配方 CAS号 C₂₅H₃₈O₅ 79902-63-9 描述 概述 A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+ signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: this product is supplied in an inactive form and requires treatment with NaOH in EtOH followed by neutralization to pH 7.2 for activation. 产品目录编号 567020 品牌系列 Calbiochem®
同义词 MK-733, L-Type Calcium Channel Blocker VI 参考 参考 Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.产品信息 CAS号 79902-63-9 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₂₅H₃₈O₅ 化学配方 C₂₅H₃₈O₅ Molar Mass 418.6 可逆 N 结构配方图像 生物信息 主靶 farnesylation 纯度 ≥98% by HPLC 理化信息 细胞可渗透 N 污染物 Heavy metals: <20 ppm 重金属 ≤20 ppm 溶解度 DMSO or EtOH GHS安全信息 RTECS EK7798000 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately.
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