merck millipore,默克密理愽
  • merck millipore,默克密理博,566323,SIRT1/2 Inhibitor IV, Cambinol

  • merck millipore,默克密理博,566323,SIRT1/2 Inhibitor IV, Cambinol

    产品名称：SIRT1/2 Inhibitor IV, Cambinol
    产品型号：566323
    The SIRT1/2 Inhibitor IV, Cambinol, also referenced under CAS 14513-15-6, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,566323,SIRT1/2 Inhibitor IV, Cambinol

  • 产品介绍
  • merck millipore,默克密理博,566323,SIRT1/2 Inhibitor IV, Cambinol

    重要规格表

    经验配方 CAS号
    C₂₁H₁₆N₂O₂S14513-15-6
    描述
    概述 A cell-permeable β-naphthol compound that inhibits the NAD-dependent deacetylase activity of hSIRT1 and hSIRT2 (IC50 = 56 µM and 59 µM, respectively) in a substrate-, but not NAD-, competitive manner. It inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 µM) and exhibits no inhibition against class I and II HDACs. Cambinol-induced apoptosis in BCL6-expressing Burkitt lymphoma cell lines has been attributed to the hyperacetylation of BCL6 and p53. Shown to effectively inhibit xenografted Daudi Burkitt lymphoma growth in mice in vivo.
    产品目录编号 566323
    品牌系列 Calbiochem®
    同义词 5-(2-Hydroxy-naphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, NSC-112546, SIRT1 Inhibitor II, SIRT2 Inhibitor VI
    参考
    参考 Heltweg, B., et al. 2006. Cancer Res. 66, 4368.
    产品信息
    CAS号 14513-15-6
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₁H₁₆N₂O₂S
    化学配方 C₂₁H₁₆N₂O₂S
    Molar Mass 360.4
    可逆 N
    结构配方图像
    生物信息
    主靶 hSIRT1 and hSIRT2
    主靶IC50 56 µM and 59 µM against the NAD-dependent deacetylase activity of hSIRT1 and hSIRT2, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,566323,SIRT1/2 Inhibitor IV, Cambinol

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