merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1488,Anti-HIRA Antibody, clone WC119

  • merck millipore,默克密理博,04-1488,Anti-HIRA Antibody, clone WC119

    产品名称：Anti-HIRA Antibody, clone WC119
    产品型号：04-1488
    Anti-HIRA Antibody, clone WC119 is a Mouse Monoclonal Antibody for detection of HIRA also known as HIR (histone cell cycle regulation defective) homolog & has been validated in WB & IP.

    merck millipore,默克密理博,04-1488,Anti-HIRA Antibody, clone WC119

  • 产品介绍
  • merck millipore,默克密理博,04-1488,Anti-HIRA Antibody, clone WC119

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-1488
    描述 Anti-HIRA Antibody, clone WC119
    Alternate Names
    • TUP1-like enhancer of split protein 1
    • DiGeorge critical region gene 1
    • HIR (histone cell cycle regulation defective) homolog A (S. cerevisiae)
    • HIR histone cell cycle regulation defective homolog A
    • HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
    背景信息 HIRA (TUP1 like enhancer of split protein 1) is a protein localized primarily in the nucleus. It functions as a histone chaparone to preferentially place histone H3.3 on nucleosome. It is broadly expressed in a variety of tissues and is expressed during embryogenesis. Data suggests HIRA plays a part in mechanisms of transcriptional regulation similar to that played by yeast HIR1 and HIR2 together. The HIRA protein has been shown to interact with HIRIP3, HIRIP5, histones H2B and H4, and PAX3. HIRA may play a part in the etiology of the DiGeorge syndrome (DGS), a developmental disorder. The clinical features of this disease include absence or hypoplasia of the thymus and parathyroid glands, cardiovascular malformations, facial dysplasia, a cleft palate and mental retardation.
    产品信息
    格式 Purified
    控制
    • NIH/3T3 cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-HIRA Antibody, clone WC119 is a Mouse Monoclonal Antibody for detection of HIRA also known as HIR (histone cell cycle regulation defective) homolog & has been validated in WB & IP.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Hall, C., et al. (2001). Molecular and Cellular Biology. 21(5):1854-1865.)
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human HIRA.
    表位 Unknown
    克隆 WC119
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes HIRA.
    同种型 IgG1κ
    品种反应性 HumanMouse
    Species Reactivity Note Demonstrated to react with mouse. Predicted to react with human based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_003316.3
    Entrez基因汇总 This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq].
    基因符号
    • TUPLE1
    • HIRA
    • DGCR1
    • HIR
    • TUP1
    纯化方法 Protein G purfied
    UniProt编号
    • P54198
    UniProt汇总 FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

    SUBUNIT STRUCTURE: Interacts with histone H3F3B, PAX3 and PAX7 By similarity. Interacts with CCNA1, HIRIP3, NFU1/HIRIP5 and histone H2B. Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1.

    SUBCELLULAR LOCATION: Nucleus. Note: Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.

    TISSUE SPECIFICTY: Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. Ref.6

    DEVELOPMENTAL STAGE: Expressed during embryogenesis.

    PTM: Sumoylated.

    Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo.

    INVOLVEMENT IN DISEASE: May play a part in the etiology of the DiGeorge syndrome (DGS), a developmental disorder due to an abnormal development of the third and fourth pharyngeal pouches. The clinical features include absence or hypoplasia of the thymus and parathyroid glands, cardiovascular malformations, facial dysplasia, a cleft palate and mental retardation.

    SEQUENCE SIMILARITIES: Belongs to the WD repeat HIR1 family.

    Contains 8 WD repeats.
    产品使用声明
    质量保证 Evaluated by Western Blot in NIH/3T3 cell lysate.

    Western Blot Analysis: 0.44 µg/ml of this antibody detected HIRA on 10 µg of NIH/3T3 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-1488,Anti-HIRA Antibody, clone WC119

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