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品种反应性 主要应用 宿主 格式 抗体类型 M, R IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC299 描述 Anti-FFAR2 Antibody/GPR43 Alternate Names - FFAR2/GPR43
- Free fatty acid receptor 2
- G-protein coupled receptor 43
背景信息 Free fatty acid receptor 2 (FFAR2), also known as G-protein coupled receptor 43 (GPR43), functions as the cell membrane receptor for short chain fatty acids that ultimately stimulates G protein coupled, inhibitory (Gi) signals via the adenylate cyclase pathway. FFAR2/GPR43 is found expressed in leukocytes in the lamina propria of the small intestine mostly but some expression can be also be found in splenocytes, adipose tissue, and enteroendocrine cells of the gut. Interesting, FFAR2/GPR43 because it senses short chain fatty acids which are often key metabolites of gut microbiota, it may serve as a biological sensor to regulate the activity of regulatory T cells and the immune response in diseases such as colitis. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-FFAR2 Antibody/GPR43 is validated for use in Western Blotting and Immunohistochemistry for the detection of FFAR2/GPR43. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western Blotting Analysis: 1.0 µg/mL from a representative lot detected FFAR2/GPR43 in 10 µg of RAW264.7 cell lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FFAR2/GPR43 in mouse kidney and mouse liver tissue.生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the cytoplasmic domain of human FFAR2/GPR43. 表位 Cytoplasmic domain 浓缩 Please refer to lot specific datasheet. 宿主 Rabbit 品种反应性 MouseRat Species Reactivity Note Rat, Mouse. Predicted to react with Human based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005297
基因符号 - GPR43
- FFAR2
纯化方法 Affinity purified UniProt编号 - O15552
产品使用声明 质量保证 Evaluated by Western Blotting in CHEM-1 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected FFAR2/GPR43 in 10 µg of CHEM-1 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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