merck millipore,默克密理愽
  • merck millipore,默克密理博,407248,IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem

  • merck millipore,默克密理博,407248,IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem

    产品名称：IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem
    产品型号：407248
    The IGF-1R Inhibitor II, also referenced under CAS 196868-63-0, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appl More>>

    merck millipore,默克密理博,407248,IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,407248,IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₆ClN₃O₂196868-63-0
    描述
    概述 A cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC50 = 12 µM in inhibiting ligand-induced autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth both in vitro (IC50 = 8 and 15 µM for MCF-7 and MCNeuA, respectively) and in mice in vivo (80% reduction, 100 mg/kg thrice a week, i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.
    产品目录编号 407248
    品牌系列 Calbiochem®
    同义词 N-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401
    参考
    参考 Gable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.
    产品信息
    CAS号 196868-63-0
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₁₈H₁₆ClN₃O₂
    化学配方 C₁₈H₁₆ClN₃O₂
    Molar Mass 341.8
    可逆 N
    结构配方图像
    生物信息
    主靶 IGF-1R
    主靶IC50 12 µM in inhibiting ligand-induced IGF-1R autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay; 8 and 15 µM in reducing IGF-1R-dependent tumor cell growth both in vitro for MCF-7 and MCNeuA, respectively
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,407248,IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem

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