merck millipore,默克密理愽
  • merck millipore,默克密理博,565788,β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem

  • merck millipore,默克密理博,565788,β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem

    产品名称：β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem
    产品型号：565788
    The β-Secretase Inhibitor IV, also referenced under CAS 797035-11-1, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

    merck millipore,默克密理博,565788,β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,565788,β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₁H₃₈N₄O₅S797035-11-1
    描述
    概述 A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 565794).

    Please note that the molecular weight for this compound is batch-specific due to variable water content.
    产品目录编号 565788
    品牌系列 Calbiochem®
    参考
    参考 Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.
    产品信息
    CAS号 797035-11-1
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₃₁H₃₈N₄O₅S
    化学配方 C₃₁H₃₈N₄O₅S
    可逆 N
    结构配方图像
    生物信息
    主靶 BACE-1 human
    主靶IC50 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,565788,β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem

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