merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3872,Anti-PPAR γ Antibody, isoform 1&2

  • merck millipore,默克密理博,MAB3872,Anti-PPAR γ Antibody, isoform 1&2

    产品名称：Anti-PPAR γ Antibody, isoform 1&2
    产品型号：MAB3872
    Anti-PPAR γ Antibody, isoform 1&2 is a Mouse Monoclonal Antibody for detection of PPAR gamma also known as Peroxisome Proliferator Activated Receptor γ & has been validated in ELISA, ICC & WB.

    merck millipore,默克密理博,MAB3872,Anti-PPAR γ Antibody, isoform 1&2

  • 产品介绍
  • merck millipore,默克密理博,MAB3872,Anti-PPAR γ Antibody, isoform 1&2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWB, ELISA, ICCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB3872
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-PPAR γ Antibody, isoform 1&2
    Alternate Names
    • PPAR gamma
    背景信息 Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in lipid transport and metabolism. As such, their roles in chronic diseases such as diabetes, obesity, atherosclerosis and cancer are heavily investigated. Transcriptional activity of PPARs is regulated by fatty acid binding. Three PPAR isotypes have been identified: a, b and g. PPARg stimulates lipolysis of circulating triglycerides and the subsequent uptake of fatty acids into adipose cells. PPARs can bind to DNA only as a heterodimer with the retinoid X receptor (RXR).
    产品信息
    格式 Ascites
    控制
    • THP-1 cell lysate, 3T3-L1 cell lysate or U-937 cell lysate
    演示 Ascites fluid containing no preservatives.
    应用
    应用 Anti-PPAR γ Antibody, isoform 1&2 is a Mouse Monoclonal Antibody for detection of PPAR gamma also known as Peroxisome Proliferator Activated Receptor γ & has been validated in ELISA, ICC & WB.
    主要应用
    • Western Blotting
    • ELISA
    • Immunocytochemistry
    应用说明 Western blot: 1:500-1:5,000

    Immunocytochemistry: 1:500-1:5,000

    ELISA: 1:500-1:5,000

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide from amino acids 107-121 of human PPAR gamma2.
    表位 isoform 1&2
    克隆 1H4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with human PPAR gamma2. The antibody also reacts with PPAR gamma1 due to immunogen sequence homology. The immunogen shows no homology with PPAR alpha or PPAR beta.
    同种型 IgG1
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_138712.3
    • NM_005037.5
    • NM_015869.4
    • NM_138711.3
    Entrez基因汇总 This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
    基因符号
    • PPARG1
    • PPARG
    • NR1C3
    • PPARG2
    • PPAR-gamma
    纯化方法 Unpurified
    UniProt编号
    • P37231
    UniProt汇总 FUNCTION: SwissProt: P37231 # Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
    SIZE: 505 amino acids; 57620 Da
    SUBUNIT: Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes (By similarity). Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs. Interacts with TGFB1I1.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also are detectable in placenta, lung and ovary.
    DISEASE: SwissProt: P37231 # Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. & Defects in PPARG may be associated with susceptibility to obesity [MIM:601665]. & Defects in PPARG may be associated with colon cancer. & Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia. & Variation in PPARG is associated with carotid intimal medial thickness 1 (CIMT1) [MIM:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors.
    SIMILARITY: SwissProt: P37231 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB3872,Anti-PPAR γ Antibody, isoform 1&2

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