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经验配方 CAS号 C₉H₄Cl₂O₂ 51050-59-0 描述 概述 A potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards β-lactamases. Effective concentration: 5-100 µM; t½ = 20 min at pH 7.5. 产品目录编号 287815 品牌系列 Calbiochem®
参考 参考 Cain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
Odake, S., et al. 1991. Biochemistry 30, 2217.
Harper, J.W., et al. 1985. Biochemistry 24, 1831.产品信息 CAS号 51050-59-0 具有ATP竞争性 N 形式 White lyophilized solid Hill配方 C₉H₄Cl₂O₂ 化学配方 C₉H₄Cl₂O₂ Molar Mass 215.0 可逆 N 结构配方图像 生物信息 主靶 serine proteases 主靶IC50 5-100 µM 纯度 ≥99% by elemental analysis 理化信息 细胞可渗透 N 溶解度 DMF or DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
防潮 Protect from moisture
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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