merck millipore,默克密理博,04-433,Anti-Bak Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-433,Anti-Bak Antibody, rabbit monoclonal
产品名称：Anti-Bak Antibody, rabbit monoclonal
产品型号：04-433
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Bak Antibody, Rabbit detects level of Bak & has More>>

merck millipore,默克密理博,04-433,Anti-Bak Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-433,Anti-Bak Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Human Only	WB, FC	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-433
品牌系列	Upstate
商名	Upstate
描述	Anti-Bak Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Bak Antibody, Rabbit detects level of Bak & has been published & validated for use in FC, IF, WB, IH(P).
主要应用	Western Blotting Flow Cytometry

生物信息
免疫原品种	KLH-conjugated synthetic peptide corresponding to the N-terminal region of human Bak.
宿主	Rabbit
特异性	Recognizes a region near the N-terminus domain of human Bak.
同种型	IgG
品种反应性	Human Only
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_001188.3
Entrez基因汇总	The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
基因符号	MGC117255 BAK1 CDN1 BAK BAK-LIKE MGC3887 BCL2L7 OTTHUMP00000039620
UniProt编号	Q16611
UniProt汇总	FUNCTION: SwissProt: Q16611 # In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a repressor Bcl-2 or its adenovirus homolog E1B 19k protein. SIZE: 211 amino acids; 23409 Da SUBUNIT: Forms heterodimers with Bcl-2, E1B 19k protein, and Bcl- X(L). SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle. DOMAIN:SwissProt: Q16611 Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. SIMILARITY: Belongs to the Bcl-2 family.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.