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描述 产品目录编号 14-916M 商名 - Upstate
描述 PEK, active 概述 Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) 产品信息 演示 Protein in of 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution 应用 主要应用 - Kinase Assay
生物信息 来源 N-terminal 6His-tagged, recombinant, human PEK amino acids 536 – end, expressed by baculovirus in Sf21 insect cells. 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_004836
基因符号 - EIF2AK3
- PEK
- PERK
纯化方法 Purified using immobilized metal affinity chromatography. UniProt编号 - Q9NZJ5
产品使用声明 质量保证 Routinely evaluated by phosphorylation of the peptide RSRSRSRSRSRSRSR 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10μg size as catalog # 14-916 and in 250 μg as catalog # 14-916-K.
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