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经验配方 CAS号 C₂₀H₁₄FN₃O 152121-30-7 描述 概述 A potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16 nM; IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1 mg/ml solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available. 产品目录编号 559388 品牌系列 Calbiochem®
同义词 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI, p38 MAP Kinase Inhibitor II 参考 参考 Davies, S.P., et al. 2000. Biochem. J. 351, 95.
Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
Lee, J.C., et al. 1994. Nature 372, 739.产品信息 CAS号 152121-30-7 具有ATP竞争性 Y 形式 Pale yellow solid Hill配方 C₂₀H₁₄FN₃O 化学配方 C₂₀H₁₄FN₃O Molar Mass 331.3 可逆 Y 结构配方图像 生物信息 主靶 p38β 主靶IC50 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2) 主靶Ki 16 nM 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
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