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merck millipore,默克密理博,555550,Rho Kinase Inhibitor - Calbiochem
产品名称：Rho Kinase Inhibitor - Calbiochem
产品型号：555550
The Rho Kinase Inhibitor controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,555550,Rho Kinase Inhibitor - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₆H₂₁N₃O₂S • 2HCl 描述 概述 A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27 μM for PKC, and 10.1 μM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50 = 2.5 μM) in NT-2 cells. Reported to be more potent and selective than Y-27632 (Cat. Nos. 688000 and 688001). Mainly targets Aurora Kinase A, and induces polyploidization of acute megakaryocytic leukemia cells (AMKL). At 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555552) in H2O is also available. 产品目录编号 555550 品牌系列 Calbiochem®
同义词 H-1152, H-1152P, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl, ROCK Inhibitor, Dimethylfasudil (diMF, H-1152P) 参考 参考 Wen, Qiang, et al. 2012. Cell 150, 575.
Ikenoya, M., et al. 2002. J. Neurochem. 81, 9.
Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.产品信息 具有ATP竞争性 Y 形式 White solid Hill配方 C₁₆H₂₁N₃O₂S • 2HCl 化学配方 C₁₆H₂₁N₃O₂S • 2HCl Molar Mass 392.3 吸湿 Hygroscopic
可逆 Y 结构配方图像 生物信息 主靶 ROCK 主靶Ki 1.6 nM against G-protein Rho-associated kinase 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 H₂O or MeOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,17-680,ChIPAb+ Monomethyl-Histone H3 (Lys9) - ChIP Validated Antibody and Primer Set
下一件merck millipore产品：merck millipore,默克密理博,201102,Bilirubin Conjugate, Ditaurate, Disodium Salt - Calbiochem
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