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merck millipore,默克密理博,04-1526,Anti-Vitamin D receptor Antibody, clone 9A7
产品名称：Anti-Vitamin D receptor Antibody, clone 9A7
产品型号：04-1526
Detect Vitamin D receptor using this Anti-Vitamin D receptor Antibody, clone 9A7 validated for use in WB, IH(P) & IP.
merck millipore,默克密理博,04-1526,Anti-Vitamin D receptor Antibody, clone 9A7
- 产品介绍
Replacement Information Replacement Information 04-1526 is a recommended replacement for MAB1360. 重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Vrt, H WB R Purified Monoclonal Antibody 描述 产品目录编号 04-1526 Replaces MAB1360 描述 Anti-Vitamin D receptor Antibody, clone 9A7 Alternate Names - vitamin D (1,25-dihydroxyvitamin D3) receptor
- 1,25-dihydroxyvitamin D3 receptor
- Nuclear receptor subfamily 1 group I member 1
- vitamin D (1,25- dihydroxyvitamin D3) receptor
背景信息 Vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or transrepression of specific gene products. In humans, the vitamin D receptor is encoded by the VDR gene. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows similarity of sequence to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. 产品信息 格式 Purified 控制 - MCF7 cell lysate
演示 Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl and 0.05% sodium azide. 应用 应用 Detect Vitamin D receptor using this Anti-Vitamin D receptor Antibody, clone 9A7 validated for use in WB, IH(P) & IP. 主要应用 - Western Blotting
应用说明 Immunohistochemistry (paraffin):
Optimal Staining with Citrate, pH 6.0. Epitope Retrieval: Hypothalamus Neurons.
Immunoprecipitation: A previous lot of this antibody was used in IP.
Blocking: A previous lot was used in blocking/inhibition assays.
Purification: A previous lot was used for purification purposes.
生物信息 免疫原品种 Partially purified chicken intestinal vitamin D receptor. 表位 a.a. 89-105 克隆 9A7 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 特异性 This antibody detects vitamin D receptor. 同种型 IgG2bκ 品种反应性 VertebratesHuman Species Reactivity Note Human. Broad species reactivity expected. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000376.2
基因符号 - NR1I1
纯化方法 Protein G purfied UniProt编号 - P11473
UniProt汇总 FUNCTION: Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Plays a central role in calcium homeostasis.
SUBUNIT STRUCTURE: Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes.
SUBCELLULAR LOCATION: Nucleus.
DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
POLYMORPHISM: Genetic variations in VDR may determine Mycobacterium tuberculosis susceptibility [MIM:607948].
INVOLVEMENT IN DISEASE: Defects in VDR are the cause of type IIA rickets [MIM:277440]; also known as hypocalcemic vitamin D-resistant rickets (HVDRR). HVDRR is most frequently an autosomal recessive disorder characterized by severe rickets, hypocalcemia and secondary hyperparathyroidism.
SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
SEQUENCE CAUTION: The sequence AAP88938.1 differs from that shown. Reason: Erroneous gene model prediction.
产品使用声明 质量保证 Evaluated by western blot on MCF7 cell lysate.
Western Blot Analysis: 0.5-2 µg/mL of this antibody detected vitamin D receptor in MCF7 cell lysate.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8ºC from date of receipt. 包装信息 数量 100 µg
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