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merck millipore,默克密理博,MAB5346,Anti-RAR alpha Antibody, clone 76
产品名称：Anti-RAR alpha Antibody, clone 76
产品型号：MAB5346
Anti-RAR alpha Antibody, clone 763 is a Mouse Monoclonal Antibody for detection of Retinoic Acid Receptor also known as RAR alpha & has been validated in WB & IHC.
merck millipore,默克密理博,MAB5346,Anti-RAR alpha Antibody, clone 76
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB5346 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-RAR alpha Antibody, clone 76 Alternate Names - RARalpha
产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA, 50% glycerol. 应用 应用 Anti-RAR alpha Antibody, clone 763 is a Mouse Monoclonal Antibody for detection of Retinoic Acid Receptor also known as RAR alpha & has been validated in WB & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western blotting
Immunohistochemistry
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Peptide from the N-terminus of human Retinoic Acid Receptor, alpha isotype. 克隆 763 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with Retinoic Acid Receptor, alpha isotype. By Western blot MAB5346 recognizes a ~48 kDa band in rat brain hippocampal homogenate. 同种型 IgG1 品种反应性 RatHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001024809.2
- NM_001033603.1
- NM_000964.2
基因符号 - RAR
- RARA
- RAR-alpha
- NR1B1
UniProt编号 - P10276
UniProt汇总 FUNCTION: SwissProt: P10276 # This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.
SIZE: 462 amino acids; 50771 Da
SUBUNIT: Interacts with CDK7 (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NOCA7 in a ligand- inducible manner.
SUBCELLULAR LOCATION: Nucleus.
DOMAIN: SwissProt: P10276 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
PTM: Phosphorylated. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity (By similarity).
DISEASE:SwissProt: P10276 # Chromosomal aberrations involving RARA may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM.
SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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