merck millipore,默克密理博,04-443,Anti-Caspase-9 (Pro) Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-443,Anti-Caspase-9 (Pro) Antibody, rabbit monoclonal
产品名称：Anti-Caspase-9 (Pro) Antibody, rabbit monoclonal
产品型号：04-443
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Caspase-9 (Pro) using this Anti-Caspase-9 (Pr More>>

merck millipore,默克密理博,04-443,Anti-Caspase-9 (Pro) Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-443,Anti-Caspase-9 (Pro) Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB, FC	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-443
品牌系列	Upstate
商名	Upstate
描述	Anti-Caspase-9 (Pro) Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Caspase-9 (Pro) using this Anti-Caspase-9 (Pro) Antibody, Rabbit validated for use in FC, WB, IH(P).
主要应用	Western Blotting Flow Cytometry

生物信息
免疫原品种	KLH-conjugated synthetic peptide composed of residues at the N-terminus of human Caspase-9.
宿主	Rabbit
特异性	Recognizes a region composed of residues at the N-terminus of human Pro-Caspase-9. This antibody only binds to the pro-form of Caspase-9.
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_032996.1 NM_001229.2
Entrez基因汇总	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.
基因符号	CASP-9 ICE-LAP6 MCH6 APAF3 CASPASE-9c OTTHUMP00000044594 APAF-3 CASP9
UniProt编号	P55211
UniProt汇总	FUNCTION: SwissProt: P55211 # Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. SIZE: 416 amino acids; 46281 Da SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts with the inhibitors BIRC2, BIRC4, BIRC5 and BIRC7. TISSUE SPECIFICITY: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. PTM: Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase- 3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events. SIMILARITY: SwissProt: P55211 ## Belongs to the peptidase C14 family. & Contains 1 CARD domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.