merck millipore,默克密理愽
  • merck millipore,默克密理博,550602,PKM2 Activator II, DASA - Calbiochem

  • merck millipore,默克密理博,550602,PKM2 Activator II, DASA - Calbiochem

    产品名称：PKM2 Activator II, DASA - Calbiochem
    产品型号：550602
    The PKM2 Activator II, DASA modulates the biological activity of PKM2. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,550602,PKM2 Activator II, DASA - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,550602,PKM2 Activator II, DASA - Calbiochem

    重要规格表

    经验配方
    C₁₈H₁₈F₂N₂O₆S₂
    描述
    概述 A cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
    产品目录编号 550602
    品牌系列 Calbiochem®
    同义词 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine, Pyruvate Kinase M2 Activator II
    参考
    参考 Anastasiou, D., et al. 2011. Science 334, 1278.
    Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.
    产品信息
    形式 White powder
    Hill配方 C₁₈H₁₈F₂N₂O₆S₂
    化学配方 C₁₈H₁₈F₂N₂O₆S₂
    Molar Mass 460.5
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,550602,PKM2 Activator II, DASA - Calbiochem

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