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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-644 品牌系列 Upstate
商名 - Upstate
描述 Anti-DLG1 Antibody 产品信息 格式 Purified 演示 70% storage buffer (0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide) and 30% glycerol 应用 应用 Anti-DLG1 Antibody is an antibody against DLG1 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide corresponding to amino acids 16-31 of human DLG1. 宿主 Rabbit 特异性 DLG1 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004087
基因符号 - hdlg
- DLG1
- SAP-97
- dJ1061C18.1.1
- DKFZp761P0818
- hDlg
- DLGH1
- SAP97
- DKFZp781B0426
纯化方法 Protein A purfied UniProt编号 - Q12959
UniProt汇总 FUNCTION: SwissProt: Q12959 # Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.
SIZE: 904 amino acids; 100355 Da
SUBUNIT: Homotetramer (Probable). Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3, DLGAP4 and MAP1A. May interact with HTR2A (By similarity). Interacts through its PDZ domains with GRIN2A, KCNA1, KCNA2, KCNA3, KCNA4, KCNA5, GRIA1, GPR124 and GPR125. Interacts with cytoskeleton-associated proteins EPB41 and VIL2. Found in a complex with KCNA5 and CAV3. Found in a complex with APC and CTNNB1. Interacts with CDH1 through binding to PIK3R1. Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12. Interacts through its guanylate kinase- like domain with KIF13B. May interact with TJAP1. Interacts with TOPK and the HTLV-1 viral Tax and HPV-18 E6 papillomavirus (HPV) oncoproteins.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (By similarity). Basolateral cell membrane (By similarity). Endoplasmic reticulum membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity).
TISSUE SPECIFICITY: Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles.
DOMAIN: SwissProt: Q12959 The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells. & The PDZ domains may also mediate association to membranes by binding to EPB41 and GPR124 together with the L27 domain that binds CASK and DLG2. & The L27 domain may regulate DLG1 self-association. The N- terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization.
PTM: Phosphorylation of Ser-232 regulates association with GRIN2A. Isoform 2 is phosphorylated on Ser-698. Isoform 3 is phosphorylated on Ser-665 (By similarity).
SIMILARITY: Belongs to the MAGUK family. & Contains 1 guanylate kinase-like domain. & Contains 1 L27 domain. & Contains 3 PDZ (DHR) domains. & Contains 1 SH3 domain.产品使用声明 质量保证 Routinely evaluated by immunoblot from HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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