merck millipore,默克密理愽
  • merck millipore,默克密理博,539211,Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem

  • merck millipore,默克密理博,539211,Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem

    产品名称：Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem
    产品型号：539211
    The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for More>>

    merck millipore,默克密理博,539211,Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,539211,Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₉H₆Br₄O₅Na₂ • 3H₂O17372-87-1
    描述
    概述 A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 and 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 and Suv39H2).
    产品目录编号 539211
    品牌系列 Calbiochem®
    同义词 Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
    参考
    参考 Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
    产品信息
    CAS号 17372-87-1
    形式 Reddish brown solid
    Hill配方 C₂₉H₆Br₄O₅Na₂ • 3H₂O
    化学配方 C₂₉H₆Br₄O₅Na₂ • 3H₂O
    Molar Mass 745.9
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥90%
    理化信息
    溶解度 H₂O
    安全信息
    R相 R: 36/38

    Irritating to eyes and skin.
    S相 S: 24/25-36/37/39-45

    Avoid contact with skin and eyes.
    Wear suitable protective clothing, gloves and eye/face protection.
    In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,539211,Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem

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