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merck millipore,默克密理博,539187,Proteasome Inhibitor X, PI-083 - CAS 6298-15-3 - Calbiochem
产品名称：Proteasome Inhibitor X, PI-083 - CAS 6298-15-3 - Calbiochem
产品型号：539187
The Proteasome Inhibitor X, PI-083, also referenced under CAS 6298-15-3, controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applica More>>
merck millipore,默克密理博,539187,Proteasome Inhibitor X, PI-083 - CAS 6298-15-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₁H₁₄ClN₃O₄S 6298-15-3 描述 概述 A cell-permeable, reversible 20S proteasome inhibitor with IC50 values of 1 µM, 4.5 µM and 4.5 µM for CT-L, T-L and PGPH-L respectively. Exhibits CT-L (chymotrypsin-like) and cell proliferation inhibition selectively in ovarian, pancreatic, and breast cancer cells (T80-Hras, C7-Kras, and MCF-7, respectively) over their non-transformed counterparts (T80, C7, and MCF-10A), and induction of apoptosis with IC50 values of 3.7 µM in an MTT assay on bone marrow cells isolated from multiple myeloma patients in vitro. Shown to have anti-tumor activities in a nude mouse xenograft model implanted with MCF-7 and A549 cells in vivo when dosed at 1 mpk, leading to significant tumor growth inhibition of 84%. PI-083 results in 43, 12 and 34% inhibition of tumor CT-L, T-L and PGPH activities respectively, compared to those of tumors from vehicle-treated controls, while it does not inhibit liver proteasome activities. 产品目录编号 539187 品牌系列 Calbiochem®
同义词 NSC-45382 参考 参考 Lawrence, R., et al. 2010. Bioorg. Med. Chem. 18, 5576.
Kazi, A., et al. 2009. Cell Cycle 8, 1940.产品信息 CAS号 6298-15-3 形式 Dark red solid Hill配方 C₂₁H₁₄ClN₃O₄S 化学配方 C₂₁H₁₄ClN₃O₄S Molar Mass 439.87 结构配方图像 生物信息 纯度 >95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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