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merck millipore,默克密理博,444966,MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem
产品名称：MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem
产品型号：444966
The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation app More>>
merck millipore,默克密理博,444966,MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₆H₁₄F₃IN₂O₄ 391210-10-9 描述 概述 A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo. Also available in InSolution™ format (Cat. No. 444968). 产品目录编号 444966 品牌系列 Calbiochem®
同义词 N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, PD325901, PD0325901, MEK Inhibitor III 参考 参考 Barrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
Silva, J., et al. 2008. PLoS Biol. 6, 2237.
Ying, Q.L., et al. 2008. Nature 453, 519.
Bain, J., et al. 2007. Biochem. J. 408, 297.
Solit, D.B., et al. 2006. Nature 439, 358.产品信息 CAS号 391210-10-9 形式 Off-white solid Hill配方 C₁₆H₁₄F₃IN₂O₄ 化学配方 C₁₆H₁₄F₃IN₂O₄ Molar Mass 482.2 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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