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描述 概述 Recombinant, human, wild-type p53 fused at the N-terminus to a His•Tag® sequence and expressed in E. coli. p53, a tumor suppressor, blocks transformation and inhibits tumor cell growth. Numerous mutations in the p53 gene have been characterized in human cancers. Loss or mutation of p53 function is highly correlated with tumorigenesis. The purified protein is useful in DNA binding assays and as a protein kinase substrate. 产品目录编号 506165 品牌系列 Calbiochem®
同义词 Tumor Protein p53 参考 参考 Liu, G., et al. 2003. J. Biol. Chem. 278, 17557.
Zhang, L., et al. 2000. Cancer Res. 60, 3655.
Fields, S., and Jang, S.K. 1990. Science 249, 1046.
Michalovitz, D., et al. 1990. Cell 62, 671.
Raycroft, L., et al. 1990. Science 249, 1049.
Finlay, C.A., et al. 1989. Cell 57, 1083.产品信息 形式 Liquid 配方 In 50 mM KCl, 30 mM sodium pyrophosphate, 5% glycerol, pH 7.5. Molar Mass 46420 生物信息 生物活性 Typical DNA binding assays require 0.5 ng to 2 ng of p53 protein per assay. 纯度 ≥80% by SDS-PAGE 浓缩标签 Please refer to vial label for lot-specific concentration
理化信息 污染物 Proteases: none detected 储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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