merck millipore,默克密理愽
  • merck millipore,默克密理博,04-736,Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal

  • merck millipore,默克密理博,04-736,Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal

    产品名称：Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal
    产品型号：04-736
    Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703 detects level of phospho-Akt1/PKBα (Ser473) & has been published & validated for use in WB.

    merck millipore,默克密理博,04-736,Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-736,Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbCulture SupernatantMonoclonal Antibody
    描述
    产品目录编号 04-736
    Replaces 05-736
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal
    Alternate Names
    • v-akt murine thymoma viral oncogene homolog 1
    • AKT1 kinase
    • Protein kinase B
    • RAC-alpha serine/threonine-protein kinase
    • rac protein kinase alpha
    背景信息 The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKBα or RacPK), Akt2 (also designated PKB-β or RacPK-β) and Akt3 (also designated PKB-γ or thyoma viral proto-oncogene 3). Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-β tyrosine residues 740 and 751, which bind the 85 kDa subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to generate a high level of Akt1 activity, and the phosphorylation of Thr 308 is not dependent on phosphorylation of Ser 473 in vivo. Thus, Akt proteins become phosphorylated and activated in insulin/IGF-1- stimulated cells by an upstream kinase(s). The activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin. Taken together, this data strongly suggests that the protein signals downstream of the PI kinases.
    产品信息
    格式 Culture Supernatant
    控制
    • Untreated and PDGF treated NIH-3T3 fibroblasts.
    演示 Cultured supernantant in 0.05% sodium azide
    应用
    应用 Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703 detects level of phospho-Akt1/PKBα (Ser473) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Peptide containing a pSer that corresponds to amino acid position 473 of human Akt1/PKBa
    表位 Phosphorylated Ser473
    克隆 SK703
    宿主 Rabbit
    特异性 Recognizes phosphorylated Akt1/PKBα, Mr 60 kDa. Cross-reactivity to phosphorylated Akt2 and Akt3 likely based on sequence homology.
    同种型 IgG
    品种反应性 MouseHuman
    Species Reactivity Note Human and mouse. Predicted cross-reactivity with rat, bovine, chicken, and Xenopus based on immunogen sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005163
    基因符号
    • EC 2.7.11.1
    • AKT1
    • RAC
    • PRKBA
    • RAC-ALPHA
    • PKB
    • MGC99656
    • RAC-PK-alpha
    • C-AKT
    • AKT
    修改
    • Phosphorylation
    UniProt编号
    • P31749
    产品使用声明
    质量保证 routinely evaluated by immunoblot on lysates from mouse NIH-3T3 fibroblasts treated with PDGF
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µl

    merck millipore,默克密理博,04-736,Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal

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