merck millipore,默克密理博,FCMAB309A6,Milli-Mark™ Anti-FOXP3-Alexa Fluor 647 Antibody, clone 3G3

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	FC	M	AlexaFluor®647	Monoclonal Antibody

描述
产品目录编号	FCMAB309A6
商名	Milli-Mark
描述	Milli-Mark™ Anti-FOXP3-Alexa Fluor® 647 Antibody, clone 3G3
Alternate Names	forkhead box P3 Scurfin
背景信息	The regulation of tolerance to self-antigens is a necessary biological process in order to prevent autoimmunity. CD4+ CD25+ regulatory T cells are known regulators of immune tolerance and activation. In both human and mice species, CD4+ CD25+ regulatory T cells are consistent in their expression of the transcription factor FOXP3 (forkhead box P3). FOXP3 acts as the “master switch” for the function and development of regulatory T cells. Mutations and deletions in the sequence encoding for FOXP3 expression lead to an inability to express FOXP3, causing an inability to regulate T cell development and leading to fatal autoimmune diseases such as IPEX and XLAAD. Conversely, recent studies have shown high and wide expression of FOXP3 in several cancer cell lines and tumors, indicating that FOXP3 is involved in preventing immunity against malignant tumors.

产品信息
格式	AlexaFluor®647
控制	mouse spleenocytes
演示	Purified mouse monoclonal IgG1k conjugated to Alexa Fluor 647 in PBS buffer with 15mg/mL BSA and sodium azide at 0.1%.

应用
应用	Detect FOXP3-Alexa Fluor647 using this Milli-Mark Anti-FOXP3-Alexa Fluor 647 Antibody, clone 3G3 validated for use in FC.
主要应用	Flow Cytometry

生物信息
免疫原品种	Histadine-tagged recombinant protein corresponding to the N-terminus of mouse FOXP3.
表位	N-terminus
克隆	3G3
宿主	Mouse
特异性	Antibody recognizes Mouse Forkhead box protein P3.
同种型	IgG1κ
品种反应性	Mouse
Species Reactivity Note	Tested and passed on Mouse.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_473380
Entrez基因汇总	The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
基因符号	Foxp3
纯化方法	Protein G Purified
UniProt编号	Q99JB6
UniProt汇总	Probable transcription factor. Plays a critical role in the control of immune response.

产品使用声明
质量保证	Evaluated by flow cytometry using mouse spleenocytes
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB309A6,Milli-Mark™ Anti-FOXP3-Alexa Fluor 647 Antibody, clone 3G3

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