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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-650 Replaces 04-1031; 04-1062 品牌系列 Upstate
商名 - Upstate
描述 Anti-GFAP+1 Antibody 产品信息 格式 Serum 演示 antiserum containing 0.05% sodium azide and 30% glycerol. 应用 应用 Anti-GFAP+1 Antibody is an antibody against GFAP+1 for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 synthetic peptide corresponding to a neo-C-terminus generated as a result of alternative splicing of the human GFAP mRNA (Hol et al, 2003) 宿主 Rabbit 特异性 GFAP+1 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002055.2
Entrez基因汇总 This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined. 基因符号 - FLJ45472
- GFAP
纯化方法 Serum UniProt编号 - P14136
UniProt汇总 FUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
SIZE: 432 amino acids; 49880 Da
SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.
SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family.产品使用声明 质量保证 Routinely evaluated by immunoblot of GFAP+1 protein 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,CC1024,Human Integrin αVβ5 Protein, Triton X-100 Formulation
下一件merck millipore产品：merck millipore,默克密理博,MAB312RX,Anti-Neuron Cell Surface Antigen Antibody, clone A2B5-105 (7), Alexa Fluor 488
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