merck millipore,默克密理愽
  • merck millipore,默克密理博,529659,Pro-survival Compound, DDD00033325 - Calbiochem

  • merck millipore,默克密理博,529659,Pro-survival Compound, DDD00033325 - Calbiochem

    产品名称：Pro-survival Compound, DDD00033325 - Calbiochem
    产品型号：529659
    A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background with equal or higher potency than Y-27632.

    merck millipore,默克密理博,529659,Pro-survival Compound, DDD00033325 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,529659,Pro-survival Compound, DDD00033325 - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₉N₅
    描述
    概述 A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50 = 3.9 µM), with equal or higher potency than Y-27632 ((Cat. No. 688000) in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10 µM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (> 83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10 µM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30 µM than Y-27632 without marked adverse effects for up to 120 hours.
    产品目录编号 529659
    品牌系列 Calbiochem®
    同义词 DDD00033325
    参考
    参考 Andrews, P.D., et al. 2010. Biochem. J. 432, 21.
    产品信息
    形式 Yellow syrup
    Hill配方 C₁₇H₁₉N₅
    化学配方 C₁₇H₁₉N₅
    Molar Mass 293.37
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,529659,Pro-survival Compound, DDD00033325 - Calbiochem

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