merck millipore,默克密理愽
  • merck millipore,默克密理博,528824,PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem

  • merck millipore,默克密理博,528824,PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem

    产品名称：PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem
    产品型号：528824
    The PARP Inhibitor XIV, also referenced under CAS 1104546-89-5, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,528824,PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,528824,PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₂N₂O₂1104546-89-5
    描述
    概述 A cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC50 = 7.35; IC50 = 45 nM) in a NAD+-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).
    产品目录编号 528824
    品牌系列 Calbiochem®
    同义词 4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165
    参考
    参考 Eltze, T., et al. 2008. Mol. Pharmacol. 74, 1587.
    产品信息
    CAS号 1104546-89-5
    形式 Orange solid
    Hill配方 C₁₅H₁₂N₂O₂
    化学配方 C₁₅H₁₂N₂O₂
    Molar Mass 252.3
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC (sum of two isomers)
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,528824,PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem

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