merck millipore,默克密理愽
  • merck millipore,默克密理博,528201,PNU-120596 - CAS 501925-31-1 - Calbiochem

  • merck millipore,默克密理博,528201,PNU-120596 - CAS 501925-31-1 - Calbiochem

    产品名称：PNU-120596 - CAS 501925-31-1 - Calbiochem
    产品型号：528201
    A urea derivative that acts as a potent, selective, and reversible positive allosteric modulator for the α7 subtype of neural nicotinic acetylcholine receptors

    merck millipore,默克密理博,528201,PNU-120596 - CAS 501925-31-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,528201,PNU-120596 - CAS 501925-31-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₃H₁₄ClN₃O₄501925-31-1
    描述
    概述 A urea derivative that acts as a potent, selective, and reversible positive allosteric modulator for the α7 subtype of neural nicotinic acetylcholine receptors (EC50 = 216 nM), with no significant effect on α4β2, α3β4 and α9α10 receptors. Specifically increase a-7 nAChR-mediated channel currents and channel mean open time in cultured neurons (~ 1 mM). However, it does neither affect ion selectivity nor unitary conductance. Shown to cross the blood-brain barrier. Causes conformational changes in the ligand binding domain of a7 nicotinic receptors that partially overlap with those caused by acetylcholine. Causes changes in cysteine accessibility at the inner beta sheet, transition zone, and agonist binding site. Also reported to potentiate agonist-evoked GABAergic postsynaptic inward currents in somatodendritic membrane of hippocampal interneurons.
    产品目录编号 528201
    品牌系列 Calbiochem®
    同义词 α7 Neuronal Nicotinic Acetylcholine Receptor Agonist, PNU-120596, 1-(5-chloro-2,4-dimethoxy-phenyl)-3-(5-methyl-isoxazol-3-yl)-urea, a7 nAChR agonist, PNU-120596
    参考
    参考 Hurst, R., et al. 2005. J. Neurosci. 25, 4396.
    Barron, S., et al. 2009. Mol. Pharm. 76, 253.
    产品信息
    CAS号 501925-31-1
    形式 White solid
    Hill配方 C₁₃H₁₄ClN₃O₄
    化学配方 C₁₃H₁₄ClN₃O₄
    Molar Mass 311.7
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,528201,PNU-120596 - CAS 501925-31-1 - Calbiochem

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