merck millipore,默克密理愽
  • merck millipore,默克密理博,528151,InSolution™ PARP Inhibitor VIII, PJ34 - Calbiochem

  • merck millipore,默克密理博,528151,InSolution™ PARP Inhibitor VIII, PJ34 - Calbiochem

    产品名称：InSolution™ PARP Inhibitor VIII, PJ34 - Calbiochem
    产品型号：528151
    The InSolution™ PARP Inhibitor VIII, PJ34 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,528151,InSolution™ PARP Inhibitor VIII, PJ34 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,528151,InSolution™ PARP Inhibitor VIII, PJ34 - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₇N₃O₂ • HCl
    描述
    概述 A water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528151) is also available.
    产品目录编号 528151
    品牌系列 Calbiochem®
    同义词 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl
    参考
    参考 Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
    Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
    Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
    产品信息
    形式 Liquid
    配方 A 20 mM (2 mg/301 µL) solution of PARP Inhibitor VIII, PJ34 (Cat. No. 528150) in H₂O.
    Hill配方 C₁₇H₁₇N₃O₂ • HCl
    化学配方 C₁₇H₁₇N₃O₂ • HCl
    Molar Mass 331.8
    可逆 Y
    结构配方图像
    生物信息
    主靶 PARP
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Harmful
    储存 ≤ -70°C
    避光 Protect from light
    避免冻结 / 解冻 Avoid freeze/thaw
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,528151,InSolution™ PARP Inhibitor VIII, PJ34 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,197228,BCRP Inhibitor IV, YHO-13351 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,570100,Ste11 MAPKKK Activation Inhibitor - CAS 331662-51-2 - Calbiochem


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