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经验配方 C₁₉H₃₁N₃O₆ 描述 概述 A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro. 产品目录编号 205531 品牌系列 Calbiochem®
同义词 Cathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester 参考 参考 Sever, N., et al. 2002. Biol. Chem. 383, 839.
Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.产品信息 具有ATP竞争性 N 形式 White solid Hill配方 C₁₉H₃₁N₃O₆ 化学配方 C₁₉H₃₁N₃O₆ Molar Mass 397.5 可逆 N 结构配方图像 生物信息 主靶 cathepsin B 主靶IC50 2.24 nM against cathepsin B 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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