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merck millipore,默克密理博,526560,PI 3-Kδ/γ Inhibitor XV, SW-14 - Calbiochem
产品名称：PI 3-Kδ/γ Inhibitor XV, SW-14 - Calbiochem
产品型号：526560
The PI 3-Kδ/γ Inhibitor XV, SW-14 controls the biological activity of PI 3-Kδ/γ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,526560,PI 3-Kδ/γ Inhibitor XV, SW-14 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₈H₂₂FN₇O₂ 描述 概述 A cell permeable, ATP competitive tolyl quinazolinone inhibitor of PI 3-Kδ/γ that displays 70-fold selectivity over PI 3-Kβ and 900-fold selectivity over PI 3-Kα in enzymatic assays with an IC50 = 9 nM for PI3Kδ and 21 nM for PI 3-Kγ and in a cell-based assay with an EC50 = 132 nM for PI 3-Kδ and 4.5 nM for PI 3-K γ. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs stimulated with lipopolysacharide. Additionally, TNFα production decreases dose-dependently in the same cell lines treated with 370 nM to 10 µM of compound. SW14 exhibits a stronger effect compared to that of PI 3-Kδ inhibition (SW30) or pan-PI 3-K inhibition with different anti-inflammatory profile. In contrast to PI 3-Kα/β it also shows very little anti-proliferative effects even at the highest dose tested (10 µM) in HUVEC culture only. 产品目录编号 526560 品牌系列 Calbiochem®
同义词 2-((4-amino-3-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, PI 3-K Inhibitor XV 参考 参考 Williams, O., et al. 2010. Chem Biol. 17, 123. 产品信息 形式 White powder Hill配方 C₂₈H₂₂FN₇O₂ 化学配方 C₂₈H₂₂FN₇O₂ Molar Mass 507.52 结构配方图像 生物信息 纯度 >95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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